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KMID : 1007520090180051305
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Food Science and Biotechnology
2009 Volume.18 No. 5 p.1305 ~ p.1309
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Effects of γ-Irradiation on Immunological Activities of β-Glucan
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Kim Jae-Hun
Sung Nak-Yun
Byun Eui-Hong
Kwon Sun-Kyu
Song Beom-Seok
Choi Jong-Il
Yoon Yo-Han
Kim Jin-Kyu
Byun Myung-Woo
Lee Ju-Woon
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Abstract
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This study evaluated the effects of γ-irradiation on immunomodulating properties and structural changes of β-glucan. β- Glucan solutions (10 mg/mL) were γ-irradiated at 10, 30, and 50 kGy. Splenocyte proliferation and cytokine (interferon-γ and interlukin-2) productions by γ-irradiated β-glucan were evaluated in in vivo and in vitro, and structural changes of β-glucan were also determined after γ-irradiation. γ-Irradiation on β-glucan at 50 kGy enhanced splenocyte proliferation and cytokine productions, (p<0.05) and cleft glycosidic bonds of β-glucan resulting in lower the molecular weight. These results indicate that the use of γ- irradiation on β-glucan may be useful for improving its immunological activity by lowering the molecular weight of β-glucan.
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KEYWORD
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β-glucan, irradiation, depolymerization, glycosidic bond, immunological activity
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